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Original and Efficient Synthesis of D ‐Cycloserine
Author(s) -
Li Xiaomeng,
Meng Xia,
Duan Hongdong,
Wang Lizhen,
Wang Shixiao,
Zhang Yi,
Qin Dawei
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900316
Subject(s) - cycloserine , mycobacterium tuberculosis , chemistry , stereochemistry , tuberculosis , biochemistry , antibiotics , medicine , pathology
A simple pathway for the preparation of D ‐cycloserine is presented. The intermediates and D ‐cycloserine were characterized by FT‐IR, 1 H‐NMR spectra and elemental analysis. D ‐Cycloserine can inhibit the growth of Mycobacterium tuberculosis and can be used as a second‐line drug for the treatment of tuberculosis, especially for the use in developing countries.