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Design and Synthesis of 2‐Phenoxynicotinic Acid Hydrazides as Anti‐inflammatory and Analgesic Agents
Author(s) -
Moradi Alireza,
Navidpour Latifeh,
Amini Mohsen,
Sadeghian Hamid,
Shadnia Hooman,
Firouzi Omidreza,
Miri Ramin,
Ebrahimi Seyed Esmaeil Sadat,
Abdollahi Mohammad,
Zahmatkesh Mona Haddad,
Shafiee Abbas
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900294
Subject(s) - mefenamic acid , analgesic , chemistry , anti inflammatory , substituent , analgesic agents , pharmacology , stereochemistry , biological activity , drug , in vitro , chemical synthesis , biochemistry , medicine , chromatography
Abstract A series of 2‐phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti‐inflammatory activities. Several compounds having an unsubstituted phenyl/4‐pyridyl or C‐4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti‐inflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti‐inflammatory activity were subjected to in vitro COX‐1/COX‐2 inhibition assays and showed moderate to good COX‐1 and weak COX‐2 inhibition activities.