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Synthesis and in‐vitro Cytotoxic Evaluation of Novel Pyridazin‐4‐one Derivatives
Author(s) -
Mojahidi Souad,
Rakib El Mostapha,
Sekkak Hanan,
Abouricha Said,
Benchat Nouredine,
Mousse Hassan Ait,
Zyad Abdelmajid
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900290
Subject(s) - cytotoxic t cell , chemistry , in vitro , pyridazine , cell culture , mastocytoma , stereochemistry , cytotoxicity , chemical synthesis , bicyclic molecule , combinatorial chemistry , biochemistry , biology , genetics
Abstract A new series of N ‐aryl‐4‐oxo‐1,4‐dihydro‐pyridazine‐3‐carboxylic acids has been synthesized by condensation of aryldiazonium with 4‐hydroxy‐6‐methyl‐2‐pyrone. Some of these compounds exhibited in‐vitro cytotoxic activity with moderate to excellent growth inhibition against the murine P815 mastocytoma cell line. Compound 5b showed an important cytotoxic activity against cell line P815 (IC 50 = 0.40 μg/mL).