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Facile Synthesis and Antibacterial, Antitubercular, and Anticancer Activities of Novel 1,4‐Dihydropyridines
Author(s) -
Sirisha Kalam,
Achaiah Garlapati,
Reddy Vanga Malla
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900243
Subject(s) - ammonium acetate , chemistry , aldehyde , combinatorial chemistry , antibacterial activity , condensation reaction , organic chemistry , chemical synthesis , one pot synthesis , in vitro , bacteria , high performance liquid chromatography , catalysis , biochemistry , biology , genetics
A series of twenty new 4‐substituted‐2,6‐dimethyl‐3,5‐bis‐ N ‐(heteroaryl)‐carbamoyl‐1,4‐dihydropyridines have been prepared from a three‐component one‐pot condensation reaction of N ‐heteroaryl acetoacetamide, an aromatic/heteroaromatic aldehyde, and ammonium acetate under four different experimental conditions. Except for the conventional method, all the experimental conditions were simple, eco‐friendly, economical, and the reactions were rapid and high‐yielding. The methods employed have been compared in terms of yields, cost, and simplicity. The synthesized compounds were characterized by different spectroscopic techniques and evaluated for their in‐vitro anticancer, antibacterial, and antitubercular activities. Amongst the compounds tested, compound 25 exhibited the highest anticancer activity while compounds 14 and 18 exhibited significant antibacterial and antitubercular activities.