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Synthesis and Antioxidant Activity of New Pyridines Containing Gallate Moieties
Author(s) -
ElEbiary Nora M. A.,
Swellem Randa H.,
Mossa AbdelTawab H.,
Nawwar Galal A. M.
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900222
Subject(s) - pyrogallol , antioxidant , chemistry , moiety , gallate , propyl gallate , dpph , methyl gallate , scavenging , chemical synthesis , organic chemistry , stereochemistry , gallic acid , biochemistry , nuclear chemistry , in vitro
Pyridines containing the galloyl moiety have been prepared utilizing 4‐acetyl pyrogallol. In addition, fused pyridines were synthesized from the obtained pyridines via further chemical transformations. The results indicated that compound 4a showed stronger DPPH scavenging activity than the other compounds, and the scavenging effect decreased in the following order 4a > t‐BHQ > 2a > 2b > 3a > 3b > 4b . Accordingly, other antioxidant assays were conducted for 4a . The results suggested that compound 4a could be a good antioxidant candidate. The absence of mortality of rats receiving 5000 mg/kg body weight of 4a as single oral dose may indicate that it could be a safe antioxidant and may be used for further studies.