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Synthesis and Evaluation of Novel Indolylthiadiazinoazetidinones and Indolylthiadiazinothiazolidinones as Antimicrobial Agents
Author(s) -
Kumar Vikas,
Sharma Suneel Kumar,
Singh Sheoraj,
Kumar Ashok,
Sharma Shalabh
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900203
Subject(s) - antimicrobial , chemistry , antifungal , aryl , alkoxy group , minimum inhibitory concentration , stereochemistry , antibacterial activity , combinatorial chemistry , antibacterial agent , organic chemistry , bacteria , antibiotics , microbiology and biotechnology , biochemistry , biology , alkyl , genetics
Some new 5‐methoxy/ethoxy‐2,3‐[2′‐(3′′‐chloro‐2′′‐oxo‐4′′‐substituted‐aryl‐1′′‐azetidinyl)‐1′,3′,4′‐thiadiazino]indoles 13–20 and 5‐methoxy/ethoxy‐2,3‐[2′‐(2′′‐substituted‐aryl‐4′′‐oxo‐1′′,3′′‐thiazolidin‐3′′‐yl)‐1′,3′,4′‐thiadiazino]indoles 21–28 have been synthesized from 5‐methoxy/ethoxy‐2,3‐[2′‐(substituted‐benzylidinylimino)‐1′,3′,4′‐thiadiazino]indoles 5–12 . These newly synthesized compounds were characterized by elemental and spectral analysis. Further, compounds 5–28 of the present series have been screened for their antibacterial and antifungal activities. Both minimal inhibitory concentration (MIC) and inhibition zones were determined in order to monitor the efficacy of the synthesized compounds. Compounds 14 and 16 were found to be the most potent members of the present series, they showed maximal antibacterial and antifungal properties much better than the standard drugs.