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Synthesis and Antistaphylococcal Activity of N ‐Substituted‐1 H ‐benzimidazole‐sulphonamides
Author(s) -
Püsküllü M. Orhan,
Yıldız Sulhiye,
Göker Hakan
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900199
Subject(s) - benzimidazole , staphylococcus aureus , antibacterial activity , chemistry , antibacterial agent , stereochemistry , staphylococcus , antibiotics , microbiology and biotechnology , medicinal chemistry , bacteria , organic chemistry , biology , biochemistry , genetics
A series of N ‐substituted‐1 H ‐benzimidazole‐5(6)‐sulfonamides and 3‐(5,6‐dichloro‐1 H ‐benzimidazol‐2‐yl)‐ N ‐substituted benzensulfonamides were synthesized and evaluated for antibacterial activity against Staphylococcus aureus and methicillin‐resistant S. aureus (MRSA). Certain compounds inhibit bacterial growth with low MIC (μg/mL) values. The most active compounds 30 , 31 , and 32 have the lowest MIC values with 0.39 to 0.19 μg/mL. Among the compounds having sulfonamido moities, 16 , 23 , and 24 exhibited the strongest antibacterial activity with 1.56 μg/mL MIC values.