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Design, Synthesis, and Pharmacological Investigation of Iodined Salicylimines, New Prototypes of Antimicrobial Drug Candidates
Author(s) -
Xu SuoPing,
Lv PengCheng,
Shi Lei,
Zhu HaiLiang
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900129
Subject(s) - enterobacter cloacae , antimicrobial , bacillus subtilis , staphylococcus aureus , chemistry , antibacterial activity , pseudomonas aeruginosa , microbiology and biotechnology , escherichia coli , enterococcus faecalis , bacteria , phenol , streptococcus , antibacterial agent , antibiotics , biology , biochemistry , enterobacteriaceae , organic chemistry , genetics , gene
A series of 3,5‐diiodo‐salicylalidene Schiff bases (compounds 1–35 ) has been synthesized and tested for antimicrobial activity. The compounds were assayed for antibacterial activities by the MTT method. Some of the compounds inhibit the growth of a broad range of bacteria including the species of Bacillus subtilis , Staphylococcus aureus , Streptococcus faecalis , Pseudomonas aeruginosa , Escherichia coli , and Enterobacter cloacae . Among them, compounds 2‐[(4‐chloro‐phenylimino)methyl]‐4,6‐diiodo‐phenol 11 and 2,4‐diiodo‐6‐[(2‐morpholin‐4‐yl‐ethylimino)methyl]phenol 19 showed the most potent antibacterial activity with MIC of 3.1, 12.9, 3.3, 6.5, 12.9, 3.3 and 3.2, 12.8, 3.2, 12.8, 12.8, 3.2 μM against B. subtilis , S. aureus , S. faecalis , P. aeruginosa , E. Coli , and E. cloacae , respectively.