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Synthesis and In‐Vitro Anti‐Hepatitis‐B Virus Activity of 6 H ‐[1]Benzothiopyrano[4,3‐ b ] quinolin‐10‐ols
Author(s) -
Jia Wei,
Zhao Yanfang,
Li Rongdong,
Wu Yanjiao,
Li Zebiao,
Gong Ping
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900070
Subject(s) - in vitro , chemistry , hepatitis b virus , stereochemistry , virus , virology , biochemistry , biology
A series of 9‐methoxy‐6 H ‐[1]benzothiopyrano[4,3‐ b ]quinolin‐10‐ols with a Mannich side chain were synthesized and evaluated for their anti‐Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti‐HBV activity with IC 50 values less than 41 μM. Among them, compound 9b was the most effective anti‐HBV agent (IC 50 = 1.7 μM, SI = 60.3).