Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues | Zendy

Liu Wen Lu | Zendy; Zhang Jian Cun | Zendy; Jiang Fa Qin | Zendy; Fu Lei | Zendy

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Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues

Author(s) -

Liu Wen Lu,

Zhang Jian Cun,

Jiang Fa Qin,

Fu Lei

Publication year - 2009

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200900067

Subject(s) - cytotoxicity , stereochemistry , chemistry , cytotoxic t cell , in vitro , chemical synthesis , biological activity , tumor cells , cell culture , combinatorial chemistry , biochemistry , biology , cancer research , genetics

Two analogues of cryptophycin were synthesized and biologically evaluated for their in‐vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC 50 values in the μM‐range, and compound 4 was more effective than compound 3 in most assays studied.

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