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Synthesis and Cytotoxicity Studies of New Cryptophycin Analogues
Author(s) -
Liu Wen Lu,
Zhang Jian Cun,
Jiang Fa Qin,
Fu Lei
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900067
Subject(s) - cytotoxicity , stereochemistry , chemistry , cytotoxic t cell , in vitro , chemical synthesis , biological activity , tumor cells , cell culture , combinatorial chemistry , biochemistry , biology , cancer research , genetics
Two analogues of cryptophycin were synthesized and biologically evaluated for their in‐vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC 50 values in the μM‐range, and compound 4 was more effective than compound 3 in most assays studied.