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Synthesis and Cytotoxic Evaluation of 6‐(3‐Pyrazolylpropyl) Derivatives of 1,4‐Naphthohydroquinone‐1,4‐diacetate
Author(s) -
Molinari Aurora,
Oliva Alfonso,
Ojeda Claudia,
del Corral José M. Miguel,
Castro M. Angeles,
Cuevas Carmen,
San Feliciano Arturo
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200900041
Subject(s) - cytotoxicity , chemistry , cytotoxic t cell , adduct , in vitro , carcinoma , chemical synthesis , breast carcinoma , stereochemistry , biochemistry , organic chemistry , cancer , breast cancer , medicine
Several new 6‐(3‐pyrazolylpropyl) derivatives of 1,4‐naphthohydroquinone‐1,4‐diacetate (NHQ‐DA) have been prepared by chemical modifications of the Diels–Alder adduct of α‐myrcene and 1,4‐benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB‐231 breast‐adeno carcinoma, A‐549 lung carcinoma, and HT‐29 colon carcinoma. GI 50 values ranged in and below the micromolar concentration level.