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Design, Synthesis, and Biological Evaluation of Prenylated Chalcones as Vasorelaxant Agents
Author(s) -
Dong Xiaowu,
Chen Jing,
Jiang Chaoyi,
Liu Tao,
Hu Yongzhou
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800229
Subject(s) - chalcone , chemistry , substituent , prenylation , phenylephrine , stereochemistry , pharmacology , organic chemistry , enzyme , medicine , blood pressure , radiology
Abstract Five prenylated chalcones and one allylated chalcone were prepared according to the analysis based on support vector machine (SVM) classification model. Most of the synthesized chalcones showed potent vasorelaxant activities through evaluation in aortic rings with the endothelium pre‐contracted by phenylephrine (PE), indicating that the experimental activities were in good agreement with the theoretical ones. Structure‐activity relationship of these compounds showed that the substituent pattern and number of hydroxyl groups were crucial for their vasorelaxant activities and that the replacement of prenyl group with allyl group retained the potent activity.