Preparation and  in‐vitro  Evaluation of 4‐Benzylsulfanylpyridine‐2‐carbohydrazides as Potential Antituberculosis Agents | Zendy

Herzigová Petra | Zendy; Klimešová Vera | Zendy; Palát Karel | Zendy; Kaustová Jarmila | Zendy; Dahse HansMartin | Zendy; Möllmann Ute | Zendy

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Preparation and in‐vitro Evaluation of 4‐Benzylsulfanylpyridine‐2‐carbohydrazides as Potential Antituberculosis Agents

Author(s) -

Herzigová Petra,

Klimešová Vera,

Palát Karel,

Kaustová Jarmila,

Dahse HansMartin,

Möllmann Ute

Publication year - 2009

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800227

Subject(s) - antimycobacterial , mycobacterium tuberculosis , moiety , cytotoxicity , chemistry , minimum inhibitory concentration , in vitro , tuberculosis , microbiology and biotechnology , stereochemistry , biology , medicine , biochemistry , pathology

A set of 4‐benzylsulfanylpyridine‐2‐carbohydrazides was synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis , non‐tuberculous mycobacteria, and multidrug‐resistant M. tuberculosis . The activities expressed as the minimum inhibitory concentration (MIC) fall into a range of 2 to 125 μmol/L, most often 4 to 32 μmol/L. The results revealed that the substituents on the benzyl moiety do not influence the antimycobacterial efficacy. The substances exhibited similar activities against sensitive and resistant strains of M. tuberculosis . Furthermore, compounds show low antiproliferative effect and cytotoxicity.

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