Premium
Preparation and in‐vitro Evaluation of 4‐Benzylsulfanylpyridine‐2‐carbohydrazides as Potential Antituberculosis Agents
Author(s) -
Herzigová Petra,
Klimešová Vera,
Palát Karel,
Kaustová Jarmila,
Dahse HansMartin,
Möllmann Ute
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800227
Subject(s) - antimycobacterial , mycobacterium tuberculosis , moiety , cytotoxicity , chemistry , minimum inhibitory concentration , in vitro , tuberculosis , microbiology and biotechnology , stereochemistry , biology , medicine , biochemistry , pathology
A set of 4‐benzylsulfanylpyridine‐2‐carbohydrazides was synthesized and evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis , non‐tuberculous mycobacteria, and multidrug‐resistant M. tuberculosis . The activities expressed as the minimum inhibitory concentration (MIC) fall into a range of 2 to 125 μmol/L, most often 4 to 32 μmol/L. The results revealed that the substituents on the benzyl moiety do not influence the antimycobacterial efficacy. The substances exhibited similar activities against sensitive and resistant strains of M. tuberculosis . Furthermore, compounds show low antiproliferative effect and cytotoxicity.