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Breast Cancer, Estrogen Receptor and Ligands
Author(s) -
Bai Zhenlin,
Gust Ronald
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800174
Subject(s) - estrogen receptor , estrogen , breast cancer , estrogen receptor beta , estrogen related receptor gamma , estrogen receptor alpha , cancer research , estrogen related receptor alpha , receptor , chemistry , cancer , medicine , pharmacology , biology , biochemistry
This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone‐induced gene transcription and on the other hand the anti‐estrogen action against breast cancer. The characterization of the estrogen receptor ligand‐binding domain co‐crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.