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Synthesis and Antibacterial Activity of a New Series of 3‐[3‐(Substituted Phenyl)‐1‐Isonicotinoyl‐1 H ‐Pyrazol‐5‐yl]‐2 H ‐Chromen‐2‐one Derivatives
Author(s) -
Aragade Prashant,
Maddi Veeresh,
Khode Suresh,
Palkar Mahesh,
Ronad Pradeepkumar,
Mamledesai Shivalingarao,
Satyanarayana Darbhamulla
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800156
Subject(s) - antibacterial activity , chemistry , isonicotinic acid , hydrazide , triethylamine , stereochemistry , ethanol , in vitro , gram , bacteria , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , genetics , biology
A novel series of 3‐[3‐(substituted phenyl)‐1‐isonicotinoyl‐1 H ‐pyrazol‐5‐yl]‐2 H ‐chromen‐2‐one derivatives 4a – k have been synthesized by the reaction of 3‐[2,3‐dibromo‐3‐(substituted phenyl) propanoyl]‐2 H ‐chromen‐2‐one 3a – k and isonicotinic acid hydrazide in the presence of triethylamine in absolute ethanol, characterized by spectral data and screened for their in‐vitro antibacterial activity against Gram‐positive and Gram‐negative bacteria. Among the series, compounds 4e , 4i , and 4k displayed an encouraging antibacterial activity profile as compared to the reference drug ampicillin against tested bacterial strains.