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Synthesis and Cytotoxicity Screening of Piperazine‐1‐carbodithioate Derivatives of 2‐Substituted Quinazolin‐4(3 H )‐ones
Author(s) -
Cao ShengLi,
Guo YanWen,
Wang XianBo,
Zhang Mei,
Feng YuPing,
Jiang YuYang,
Wang Yue,
Gao Qian,
Ren Jian
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800148
Subject(s) - cytotoxicity , piperazine , chemistry , mtt assay , k562 cells , human liver , cell culture , cancer cell lines , combinatorial chemistry , stereochemistry , cancer cell , cancer , biochemistry , organic chemistry , in vitro , biology , genetics
A new series of piperazine‐1‐carbodithioate derivatives of 2‐substituted quinazolin‐4(3 H )‐ones were synthesized via a five‐steps procedure starting from 2‐amino‐5‐methylbenzoic acid. The cytotoxicity of the resulting compounds against A‐549 (human lung cancer), HCT‐8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.