Leishmanicidal Evaluation of Novel Synthetic Chromenes | Zendy

Alizadeh Babak Heidary | Zendy; Foroumadi Alireza | Zendy; Ardestani Susan K. | Zendy; Poorrajab Fatemeh | Zendy; Shafiee Abass | Zendy

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Leishmanicidal Evaluation of Novel Synthetic Chromenes

Author(s) -

Alizadeh Babak Heidary,

Foroumadi Alireza,

Ardestani Susan K.,

Poorrajab Fatemeh,

Shafiee Abass

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800128

Subject(s) - chemistry , aryl , stereochemistry , in vitro , biological activity , chemical synthesis , organic chemistry , biochemistry , alkyl

In the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8‐tetramethyl‐8 H ‐pyrano[2,3‐ f ]chroman‐4‐one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in‐vitro activity against Leishmania major , and some of them displayed efficient anti‐leishmanial activity. Among the compounds tested, compounds 9 (4‐(2‐chloro‐benzylidene)‐2,2,8,8‐tetramethyl‐3,4‐dihydro‐2 H ,8 H ‐pyrano[2,3‐ f ]chromene 9a and 4‐(2‐chloro‐benzyl)‐2,2,8,8‐tetramethyl‐2 H ,8 H ‐pyrano[2,3‐ f ]chromene 9b ) were the most active with an inhibitory activity of 73.4%.

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