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Leishmanicidal Evaluation of Novel Synthetic Chromenes
Author(s) -
Alizadeh Babak Heidary,
Foroumadi Alireza,
Ardestani Susan K.,
Poorrajab Fatemeh,
Shafiee Abass
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800128
Subject(s) - chemistry , aryl , stereochemistry , in vitro , biological activity , chemical synthesis , organic chemistry , biochemistry , alkyl
In the present paper, twelve chromenes were synthesized by coupling of 2,2,8,8‐tetramethyl‐8 H ‐pyrano[2,3‐ f ]chroman‐4‐one 1 with various aryl and benzylmagnesium chlorides. The synthetic compounds were examined for in‐vitro activity against Leishmania major , and some of them displayed efficient anti‐leishmanial activity. Among the compounds tested, compounds 9 (4‐(2‐chloro‐benzylidene)‐2,2,8,8‐tetramethyl‐3,4‐dihydro‐2 H ,8 H ‐pyrano[2,3‐ f ]chromene 9a and 4‐(2‐chloro‐benzyl)‐2,2,8,8‐tetramethyl‐2 H ,8 H ‐pyrano[2,3‐ f ]chromene 9b ) were the most active with an inhibitory activity of 73.4%.