Synthesis and Antimicrobial Activity of Some Novel 2‐[4‐(Substituted Piperazin‐/Piperidin‐1‐ylcarbonyl)phenyl]‐1 H ‐benzimidazole Derivatives | Zendy

Kus Canan | Zendy; Sözüdönmez Fatma | Zendy; Altanlar Nurten | Zendy

Premium

Synthesis and Antimicrobial Activity of Some Novel 2‐[4‐(Substituted Piperazin‐/Piperidin‐1‐ylcarbonyl)phenyl]‐1 H ‐benzimidazole Derivatives

Author(s) -

Kus Canan,

Sözüdönmez Fatma,

Altanlar Nurten

Publication year - 2009

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800084

Subject(s) - benzimidazole , antimicrobial , staphylococcus aureus , chemistry , antifungal , fluconazole , antibacterial activity , stereochemistry , microbiology and biotechnology , organic chemistry , bacteria , biology , genetics

In this study, we report the synthesis and antimicrobial evaluation of several new 4‐(1 H ‐benzimidazol‐2‐yl)benzamides ( 11 – 30 ) and 5‐chloro‐1‐( p ‐fluorobenzyl)‐2‐{4‐[(4‐methylpiperazin‐1‐yl)carbonyl]phenyl}‐1 H ‐benzimidazole ( 33 ). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 μg/mL against Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13 , 14, 18 , 19, and 33 with MIC values of 3.12 μg/mL which are close to fluconazole.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research