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Synthesis and Antimicrobial Activity of Some Novel 2‐[4‐(Substituted Piperazin‐/Piperidin‐1‐ylcarbonyl)phenyl]‐1 H ‐benzimidazole Derivatives
Author(s) -
Kus Canan,
Sözüdönmez Fatma,
Altanlar Nurten
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800084
Subject(s) - benzimidazole , antimicrobial , staphylococcus aureus , chemistry , antifungal , fluconazole , antibacterial activity , stereochemistry , microbiology and biotechnology , organic chemistry , bacteria , biology , genetics
In this study, we report the synthesis and antimicrobial evaluation of several new 4‐(1 H ‐benzimidazol‐2‐yl)benzamides ( 11 – 30 ) and 5‐chloro‐1‐( p ‐fluorobenzyl)‐2‐{4‐[(4‐methylpiperazin‐1‐yl)carbonyl]phenyl}‐1 H ‐benzimidazole ( 33 ). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 μg/mL against Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13 , 14, 18 , 19, and 33 with MIC values of 3.12 μg/mL which are close to fluconazole.