Synthesis and SAR Study of T‐Type Calcium Channel Blockers. Part II | Zendy

Choe Yun Jeong | Zendy; Seo Han Na | Zendy; Jung Soo Yeon | Zendy; Rhim Hyewhon | Zendy; Kim Jungahn | Zendy; Choo Dong Joon | Zendy; Lee Jae Yeol | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and SAR Study of T‐Type Calcium Channel Blockers. Part II

Author(s) -

Choe Yun Jeong,

Seo Han Na,

Jung Soo Yeon,

Rhim Hyewhon,

Kim Jungahn,

Choo Dong Joon,

Lee Jae Yeol

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800079

Subject(s) - calcium channel , chemistry , potency , derivative (finance) , stereochemistry , selectivity , calcium , combinatorial chemistry , in vitro , biochemistry , organic chemistry , economics , financial economics , catalysis

3,4‐Dihydroquinazoline derivatives have been known to be the novel and potent T‐type calcium channel blockers. From a systematic variation of 3,4‐dihydroquinazoline derivative 5c ( KYS05043 ), plausible SAR results were established. It was revealed that a 5‐(dimethylamino)pentylamino group at R 1 , a biphenyl group at R 2 , and a benzyl amido group at R 3 in the 3,4‐dihydroquinazoline backbone are closely related with the channel selectivity (T/N‐type) as well as the potency based on the discovery of 6k ( KYS05090 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research