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Synthesis and Studies on Antidepressant and Anticonvulsant Activities of Some 3‐(2‐Thienyl)pyrazoline Derivatives
Author(s) -
Ozdemir Zuhal,
Kandilci H. Burak,
Gumusel Bulent,
Calis Unsal,
Bilgin A. Altan
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800068
Subject(s) - anticonvulsant , pyrazoline , antidepressant , chemistry , pharmacology , chemical synthesis , epilepsy , medicine , medicinal chemistry , biochemistry , psychiatry , in vitro , hippocampus
In this study, the synthesis of twelve 3‐(2‐thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, 1 H‐NMR, mass spectral data, and microanalyses. In the pharmacological studies, antidepressant and anticonvulsant activities of these compounds have been screened. The antidepressant activities of the compounds were investigated by Porsolt's behavioral despair test (forced swimming) on albino mice and compared with tranylcypromine. Among the compounds examined, the compounds 9 and 12 showed significant antidepressant activity. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (metrazol) (scMet.) tests, neurotoxicities were determined by rotarod toxicity test on albino mice. Compound 8 was found to be protective against MES in the range of 30–300 mg/kg dose levels at four hours. None of the synthesized compounds showed neurotoxicity at 30–300 mg/kg dose levels.