Synthesis of Novel Substituted 7‐(Benzylideneamino)‐4‐Methyl‐2 H ‐Chromen‐2‐one Derivatives as Anti‐inflammatory and Analgesic Agents | Zendy

Ronad Pradeepkumar | Zendy; Dharbamalla Satyanarayana | Zendy; Hunshal Rajesh | Zendy; Maddi Veeresh | Zendy

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Synthesis of Novel Substituted 7‐(Benzylideneamino)‐4‐Methyl‐2 H ‐Chromen‐2‐one Derivatives as Anti‐inflammatory and Analgesic Agents

Author(s) -

Ronad Pradeepkumar,

Dharbamalla Satyanarayana,

Hunshal Rajesh,

Maddi Veeresh

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800057

Subject(s) - analgesic , chemistry , stereochemistry , moiety , anti inflammatory , schiff base , chemical synthesis , biological activity , medicinal chemistry , pharmacology , biochemistry , in vitro , medicine

A series of novel Schiff' base‐containing a 7‐amino‐4‐methylcoumarin moiety have been synthesized III a – l , characterized by spectroscopic data and studied for their anti‐inflammatory and analgesic activity. The results of the anti‐inflammatory and analgesic activity evaluation of 7‐(substituted benzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one derivatives III a – l proved to be comparable or more potent with respect to the reference drugs. In particular, compounds 7‐(4‐chlorobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III f , 7‐(2,4‐dichlorobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III g and 7‐(4‐bromobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III h exhibited potent anti‐inflammatory and analgesic activity.

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