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Synthesis of Novel Substituted 7‐(Benzylideneamino)‐4‐Methyl‐2 H ‐Chromen‐2‐one Derivatives as Anti‐inflammatory and Analgesic Agents
Author(s) -
Ronad Pradeepkumar,
Dharbamalla Satyanarayana,
Hunshal Rajesh,
Maddi Veeresh
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800057
Subject(s) - analgesic , chemistry , stereochemistry , moiety , anti inflammatory , schiff base , chemical synthesis , biological activity , medicinal chemistry , pharmacology , biochemistry , in vitro , medicine
A series of novel Schiff' base‐containing a 7‐amino‐4‐methylcoumarin moiety have been synthesized III a – l , characterized by spectroscopic data and studied for their anti‐inflammatory and analgesic activity. The results of the anti‐inflammatory and analgesic activity evaluation of 7‐(substituted benzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one derivatives III a – l proved to be comparable or more potent with respect to the reference drugs. In particular, compounds 7‐(4‐chlorobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III f , 7‐(2,4‐dichlorobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III g and 7‐(4‐bromobenzylideneamino)‐4‐methyl‐2 H ‐chromen‐2‐one III h exhibited potent anti‐inflammatory and analgesic activity.