Synthesis of 2,3‐Disubstituted 1,4‐Naphthoquinones as Antiplatelet Agents | Zendy

Lien JinCherng | Zendy; Wu ChiRei | Zendy; Hour MannJen | Zendy; Huang LiJiau | Zendy; Huang TurFu | Zendy; Kuo ShengChu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 2,3‐Disubstituted 1,4‐Naphthoquinones as Antiplatelet Agents

Author(s) -

Lien JinCherng,

Wu ChiRei,

Hour MannJen,

Huang LiJiau,

Huang TurFu,

Kuo ShengChu

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200800024

Subject(s) - chemistry , mechanism of action , naphthoquinone , stereochemistry , pharmacology , platelet aggregation , structure–activity relationship , biological activity , phospholipase a2 , 1,4 naphthoquinone , platelet , phospholipase , combinatorial chemistry , biochemistry , in vitro , enzyme , medicinal chemistry , organic chemistry , medicine

In continuing search for novel antiplatelet agents, the highly potent agent 2‐chloro‐3‐methoxycarbonylethylcarboxamido‐1,4‐naphthoquinone 2 was selected as lead compound. Structure‐activity relationships in this series were examined. Some of these compounds showed significant antiplatelet activities. Further studies on the action mechanism showed that 2‐acetamido‐3‐chloro‐1,4‐naphthoquinone 4 has a direct inhibitory action on cytosolic phospholipase A 2 (cPLA 2 ) activity in platelets.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research