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Synthesis and In‐Vitro Antibacterial Activity of 5‐Substituted 1‐Methyl‐4‐nitro‐1 H ‐imidazoles
Author(s) -
Letafat Bahram,
Emami Saeed,
Aliabadi Alireza,
Mohammadhosseini Negar,
Moshafi Mohammad Hassan,
Asadipour Ali,
Shafiee Abbas,
Foroumadi Alireza
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800022
Subject(s) - staphylococcus epidermidis , klebsiella pneumonia , antibacterial activity , agar dilution , chemistry , enterobacter aerogenes , bacteria , bacillus subtilis , gram positive bacteria , microbiology and biotechnology , imidazole , staphylococcus aureus , in vitro , antimicrobial , minimum inhibitory concentration , stereochemistry , biology , escherichia coli , organic chemistry , biochemistry , gene , genetics
Abstract A series of 5‐substituted 1‐methyl‐4‐nitro‐1 H ‐imidazole derivatives were synthesized and evaluated for in‐vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis , Bacillus subtilis , Esherichia coli, Klebsiella pneumonia, Entrobacter aerogenes , and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1‐methyl‐4‐nitro‐5‐(phenylsulfonyl)‐1 H ‐imidazole was the most potent against Gram‐positive bacteria, with a MIC value of ⪇8 μg/mL. All compounds showed no significant activity against Gram‐negative bacteria at concentrations ⪇64 μg/mL The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 μg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole.