Premium
Synthesis and Pharmacological Evaluation of N ‐(Dimethylamino)ethyl Derivatives of Benzo‐ and Pyridopyridazinones
Author(s) -
Pakulska Wanda,
Malinowski Zbigniew,
Szczesniak Aleksandra K.,
Czarnecka Elzbieta,
Epsztajn Jan
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800016
Subject(s) - chemistry , stereochemistry
New N ‐(dimethylamino)ethyl derivatives of phthalazinones and pyridopyridazinones 7 , 9 were synthesized and assayed as potential analgesic agents in the hot‐plate, tail‐flick, and writhing tests. Pharmacological assay demonstrated that eight (in ten) of the newly synthesized compounds showed antinociceptive activity. Especially, 2‐[2‐(dimethylamino)ethyl]‐4‐phenyl‐2 H ‐phthalazin‐1‐one 7a showed remarkably higher antinociceptive activity in all tests. This is connected with influence on supraspinal, spinal, and peripheral structures. The decreased sensitivity to the pain stimulus in the hot‐plate was higher than that of metamizole.