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Synthesis and In‐Vitro Activity of New 1β‐Methylcarbapenem Derivatives as Antibacterial Agents
Author(s) -
Jung MyungHo,
Hong Joon Hee,
Cho JungHyuck,
Oh ChangHyun
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800014
Subject(s) - pyrrolidine , piperidine , moiety , chemistry , antibacterial activity , oxime , in vitro , stereochemistry , chemical synthesis , ring (chemistry) , bacteria , antibacterial agent , combinatorial chemistry , organic chemistry , biochemistry , antibiotics , biology , genetics
Abstract The synthesis of a new series of 1β‐methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime‐pyrrolidine moiety showed the most potent antibacterial activity.