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Synthesis and Antiprotozoal Evaluation of New N 4 ‐(Benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thiones)
Author(s) -
Coro Julieta,
Little Susan,
Yardley Vanessa,
Suárez Margarita,
Rodríguez Hortensia,
Martín Nazario,
PerezPineiro Rolando
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800011
Subject(s) - antiprotozoal , chemistry , spermidine , in vitro , stereochemistry , organic chemistry , biochemistry , enzyme
The synthesis and in‐vitro antiprotozoal evaluation of novel N 4 ‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N 4 ‐(benzyl)spermidine is disclosed. Several of the new bis‐THTT have in‐vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.