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Synthesis, Antiplatelet and Vasorelaxing Activities of Xanthone Derivatives
Author(s) -
Lin KaiWei,
Fang SongChwan,
Hung ChiFeng,
Shieh BorJinn,
Yang ShyhChyun,
Teng CheMing,
Lin ChunNan
Publication year - 2009
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200800002
Subject(s) - chemistry , antithrombotic , platelet , arachidonic acid , pharmacology , thrombin , adenosine diphosphate , in vitro , xanthone , platelet aggregation , biochemistry , platelet activating factor , stereochemistry , enzyme , medicine , immunology
A series of ω‐aminoalkoxylxanthones was synthesized and tested in vitro for their ability to inhibit platelet aggregation and cause vasorelaxing action. Compounds 4 , 5 , 12 , 17 , and 18 showed significant antiplatelet effects on thrombin‐, arachidonic acid (AA)‐, collagen‐, and platelet activating factor (PAF)‐induced washed rabbit platelet aggregation and exhibited inhibition of primary and secondary aggregation induced by adenosine‐5'‐diphosphate (ADP) in human platelet‐rich‐plasma (PRP). Compounds 4 , 17 , and 18 revealed vasorelaxing activities in rat thoracic aorta. We concluded that these compounds may be developed as new antithrombotic agents.