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Cytotoxic‐Antineoplastic Derivatives of Prenyl‐1,2‐naphthohydroquinone
Author(s) -
Molinari Aurora,
Oliva Alfonso,
Ojeda Claudia,
del Corral José M. Miguel,
Castro M. Angeles,
Cuevas Carmen,
San Feliciano Arturo
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700259
Subject(s) - prenylation , cytotoxic t cell , chemistry , in vitro , cycloaddition , stereochemistry , biochemistry , enzyme , catalysis
Several new prenyl‐1,2‐naphthohydroquinone derivatives have been prepared by chemical modifications of Diels–Alder products which were obtained from cycloaddition of α‐myrcene to 1,2‐benzoquinone and then evaluated in vitro for their cytotoxic activity against A‐549 lung carcinoma, HT‐29 colon carcinoma, and MB‐231 breast adeno‐carcinoma culture cells. Most of them exhibited GI 50 values in the μM‐concentration level.