Investigations Concerning the Correlation of COX‐1 Inhibitory and Hydroxyl Radical Scavenging Activity | Zendy

Scholz Michael | Zendy; Ulbrich Holger | Zendy; Mattern Andreas | Zendy; Kramb JanPeter | Zendy; Kiefer Werner | Zendy; Dannhardt Gerd | Zendy

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Investigations Concerning the Correlation of COX‐1 Inhibitory and Hydroxyl Radical Scavenging Activity

Author(s) -

Scholz Michael,

Ulbrich Holger,

Mattern Andreas,

Kramb JanPeter,

Kiefer Werner,

Dannhardt Gerd

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700247

Subject(s) - chemistry , scavenging , hydroxyl radical , context (archaeology) , radical , carboxylic acid , inhibitory postsynaptic potential , stereochemistry , organic chemistry , antioxidant , paleontology , neuroscience , biology

The aim was to study the COX‐1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX‐1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.

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