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Investigations Concerning the Correlation of COX‐1 Inhibitory and Hydroxyl Radical Scavenging Activity
Author(s) -
Scholz Michael,
Ulbrich Holger,
Mattern Andreas,
Kramb JanPeter,
Kiefer Werner,
Dannhardt Gerd
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700247
Subject(s) - chemistry , scavenging , hydroxyl radical , context (archaeology) , radical , carboxylic acid , inhibitory postsynaptic potential , stereochemistry , organic chemistry , antioxidant , paleontology , neuroscience , biology
The aim was to study the COX‐1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. In general, the acids are more potent radical scavengers than the corresponding esters but there is no clear correlation with their COX‐1 inhibiting potencies. A feasible scavenging mechanism of carboxylic acids is discussed.