Selenium‐Containing Heterocycles: Synthesis and Pharmacological Activities of Some New 4‐Methylquinoline‐2(1 H ) Selenone Derivatives | Zendy

AbdelHafez Shams H. | Zendy; Hussein Mostafa A. | Zendy

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Selenium‐Containing Heterocycles: Synthesis and Pharmacological Activities of Some New 4‐Methylquinoline‐2(1 H ) Selenone Derivatives

Author(s) -

AbdelHafez Shams H.,

Hussein Mostafa A.

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700202

Subject(s) - chemistry , acetic anhydride , antifungal , acute toxicity , organic chemistry , proton nmr , stereochemistry , toxicity , catalysis , medicine , dermatology

Several selenolo[2,3‐ b ]quinolines and pyrimido[4′,5′:4,5]selenolo[2,3 ‐b ]quinolines were prepared by annulations via reaction of NaSeH with 2‐chloro‐3‐cyano‐4‐methylquinoline 1 followed by reactions with aromatic aldehydes, cycloalkanones, and acetic anhydride. Spectroscopic (IR, 1 H‐NMR, and MS) properties of the synthesized compounds are reported. Some selected compounds 5a , 7b , 7c , 8b–d , 9a , 11b , and 11d were investigated for their anti‐inflammatory and analgesic activities; in addition, the most active compounds were tested for their ulcerogenicity and acute toxicity. Moreover, some of the test compounds 7c , 9a , 11b , and 11d were screened for their antibacterial and antifungal activities.

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