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Synthesis and Antimicrobial Study of Novel 1‐Aryl‐2‐oxo‐indano[3,2‐ d ]pyrido/pyrimido[1,2‐ b ]pyrimidines
Author(s) -
Sarvesh Pandey K.,
Nizamuddin Khan
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700197
Subject(s) - chemistry , knoevenagel condensation , antimicrobial , indane , antifungal , proton nmr , aryl , carbon 13 nmr , elemental analysis , organic chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry , catalysis , medicine , alkyl , dermatology
Abstract A series of 2‐(arylidene)‐indan‐1, 3‐diones 1 were prepared by Knoevenagel reaction between indane‐1,3‐dione and the appropriate araldehydes. The α,β‐enones 1 have been used as a component of Michael addition with equimolar amounts of 2‐aminopyridine/2‐aminopyrimidine to give novel heterocyclic systems 4 and 5 , respectively. They are reported here for the first time. The structures of the newly synthesized compounds were confirmed by IR, 1 H‐NMR, 13 C‐NMR, and elemental analysis. All compounds were screened for their antibacterial and antifungal activities. Some of them showed promising activities.