Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides | Zendy

Xu GuiQing | Zendy; Zhang Chong | Zendy; Zhang Lei | Zendy; Zhou XingLu | Zendy; Yang Bo | Zendy; He QiaoJun | Zendy; Hu YongZhou | Zendy

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Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides

Author(s) -

Xu GuiQing,

Zhang Chong,

Zhang Lei,

Zhou XingLu,

Yang Bo,

He QiaoJun,

Hu YongZhou

Publication year - 2008

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700190

Subject(s) - cytotoxicity , protein kinase a , cell culture , chemistry , kinase , in vitro , cytotoxic t cell , cancer cell lines , protein kinase c , biochemistry , cancer cell , structure–activity relationship , stereochemistry , biology , cancer , genetics

A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in‐vitro cytotoxicity against various human cancer cell lines and their protein‐kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound 6b is the most promising compound against the tested cancer cell lines; 6d and 6e showed moderate protein‐kinase C inhibition. Structure–activity relationships are discussed based on the experimental data obtained.

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