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Synthesis, Cytotoxicity and Protein Kinase C Inhibition of Arylpyrrolylmaleimides
Author(s) -
Xu GuiQing,
Zhang Chong,
Zhang Lei,
Zhou XingLu,
Yang Bo,
He QiaoJun,
Hu YongZhou
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700190
Subject(s) - cytotoxicity , protein kinase a , cell culture , chemistry , kinase , in vitro , cytotoxic t cell , cancer cell lines , protein kinase c , biochemistry , cancer cell , structure–activity relationship , stereochemistry , biology , cancer , genetics
A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in‐vitro cytotoxicity against various human cancer cell lines and their protein‐kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound 6b is the most promising compound against the tested cancer cell lines; 6d and 6e showed moderate protein‐kinase C inhibition. Structure–activity relationships are discussed based on the experimental data obtained.