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Synthesis of Platensimycin Analogues and Their Antibiotic Potency
Author(s) -
Krauss Jürgen,
Knorr Veronika,
Manhardt Vera,
Scheffels Stefanie,
Bracher Franz
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700177
Subject(s) - antimicrobial , potency , chemistry , bacteria , natural product , aniline , antibacterial activity , organic chemistry , combinatorial chemistry , stereochemistry , biochemistry , biology , in vitro , genetics
Platensimycin is a natural product isolated from various strains of Streptomyces platensis which exhibits antimicrobial activity against Gram positive bacteria, including vancomycin‐ and linezolide‐resistant species. Analogues of platensimycin were synthesized from 3‐aminobenzoic acid or other aniline derivatives and several alkyl‐ and aryl‐carboxylic acids. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi.