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Anti‐Inflammatory and Analgesic Activities of Newly Synthesized Chiral Peptide Derivatives Using (3‐Benzoyl‐ 4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic Acid Ethylester as Starting Material
Author(s) -
Fakhr Issa M.,
Amr AbdelGalil E.,
Sabry Nermien, M.,
Abdalah Mohamed M.
Publication year - 2008
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700158
Subject(s) - chemistry , hydrazine (antidepressant) , acetic acid , hydrate , analgesic , reagent , organic chemistry , antipyretic , combinatorial chemistry , pharmacology , chromatography , medicine
A series of heterocyclic derivatives was synthesized using (3‐benzoyl‐4,5‐dioxo‐2‐phenyl‐pyrrolidin‐1‐yl)acetic acid ethyl ester 1 as starting material. Treatment of 1 with 1 N NaOH or hydrazine hydrate afford the corresponding acid 2 and acid hydrazides 4 and 5 , which were reacted with several reagents to produce some new peptido hetero‐organic derivatives 6–12 . The pharmacological screening showed that many of these newly synthesized compounds have good anti‐inflammatory and analgesic activities comparable to diclofenac potassium and valdecoxib as reference drugs.