Synthesis, Characterization and Cytotoxicity of Diam(m)‐ineplatinum(II) Complexes Containing β‐phenylisosuccinate Ligand | Zendy

Ye QingSong | Zendy; Lou LiGuang | Zendy; Liu ZuoYan | Zendy; Liu WeiPing | Zendy; Hou ShuQian | Zendy; Chen XiZhu | Zendy; Yu Yao | Zendy

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Synthesis, Characterization and Cytotoxicity of Diam(m)‐ineplatinum(II) Complexes Containing β‐phenylisosuccinate Ligand

Author(s) -

Ye QingSong,

Lou LiGuang,

Liu ZuoYan,

Liu WeiPing,

Hou ShuQian,

Chen XiZhu,

Yu Yao

Publication year - 2007

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700114

Subject(s) - cytotoxicity , cisplatin , carboplatin , chemistry , stereochemistry , ligand (biochemistry) , cell culture , a549 cell , cancer cell lines , cancer cell , cancer , cell , biochemistry , in vitro , chemotherapy , biology , receptor , genetics

Four diam(m)ineplatinum(II) complexes containing β‐phenylisosuccinate as the leaving groups were prepared, characterized, and evaluated for their cytotoxicity against A549/ATCC human lung cancer cell line and SGC‐7901 human gastric cancer cell line. One of the complexes, ( trans‐ 1 R, 2 R‐ diaminocyclohexane)‐β‐phenylisosuccinatoplatinum(II) 4 , was much more active than cisplatin and carboplatin.

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