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γ‐Substituted Bis(pivaloyloxymethyl)ester Analogues of Fosmidomycin and FR900098
Author(s) -
Kurz Thomas,
Behrendt Christoph,
Pein Miriam,
Kaula Uwe,
Bergmann Bärbel,
Walter Rolf D.
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700107
Subject(s) - plasmodium falciparum , stereochemistry , chemistry , in vitro , chemical synthesis , aryl , biochemistry , malaria , biology , organic chemistry , alkyl , immunology
The synthesis and in‐vitro antimalarial activity of γ‐substituted bis(pivaloyloxymethyl)ester analogues of the drug candidate fosmidomycin have been investigated. In contrast to the high antimalarial activity of α‐aryl substituted fosmidomycin analogues like α‐phenylfosmidomycin, γ‐substituted derivatives display only weak to moderate activity against the chloroquine‐sensitive strain 3D7 of Plasmodium falciparum .