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Synthesis, X‐ray Structure, and Pharmacological Activity of Some 6,6‐Disubstituted Chromeno[4,3‐ b ]‐ and Chromeno‐ [3,4‐ c ]‐quinolines
Author(s) -
Hegab Mohamed I.,
AbdelFattah AbdelSamee M.,
Yousef Nabil M.,
Nour Hany F.,
Mostafa A. M.,
Ellithey Mohey
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700089
Subject(s) - aniline , quinoline , chemistry , aniline compounds , x ray , crystal structure , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , physics , quantum mechanics
Some chromeno[4,3‐ b ]quinolines 4a–i were obtained from β‐chloro carboxyaldehydes 3a–c with different aniline derivatives namely, aniline, 4‐fluoroaniline, and 2‐aminophenol. Surprisingly, 3a–c reacted with 2‐aminothiophenol and afforded the chromeno[3,4‐ c ]quinoline derivatives 5a–c . Single‐crystal X‐ray diffraction studies of 4e and 5b provided good support for the established structure. Compounds 4b and 5b showed significant anti‐inflammatory and ulcerogenic score activities compared to that of indomethacin.