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Synthesis and Antioxidant Capacities of Some New Benzimidazole Derivatives
Author(s) -
AyhanKılcıgil Gülgün,
Kus Canan,
Özdamar Elçin D.,
CanEke Benay,
Iscan Mümtaz
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700088
Subject(s) - benzimidazole , chemistry , antioxidant , chemical synthesis , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , in vitro
Abstract In this study, we prepared some new oxadiazolyl benzimidazole derivatives and investigated their antioxidant properties by determination of microsomal NADPH‐dependent inhibition of lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O ‐deethylase activity (EROD assay). Some of these compounds 20, 23 had slightly inhibitory effects (28%) on the lipid peroxidation levels at 10 –3 M concentration lower than standard BHT (65%). 5‐[2‐(Phenyl)‐benzimidazol‐1‐yl‐methyl]‐2‐mercapto‐[1,3,4]‐oxadiazole 16 was found to be more active than caffeine on the ethoxyresorufin O ‐deethylase activity with an IC 50 value of 2.0 6 10 –4 M.