Synthesis and Evaluation of Novel  E ‐2‐(2‐Thienyl)‐ and  Z ‐2‐(3‐Thienyl)‐3‐Arylacrylonitriles as Antifungal and Anticancer Agents | Zendy

Quiroga Jairo | Zendy; Cobo Débora | Zendy; Insuasty Braulio | Zendy; Abonía Rodrigo | Zendy; Nogueras Manuel | Zendy; Cobo Justo | Zendy; Vásquez Yelkaira | Zendy; Gupta Mahabir | Zendy; Derita Marcos | Zendy; Zacchino Susana | Zendy

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Synthesis and Evaluation of Novel E ‐2‐(2‐Thienyl)‐ and Z ‐2‐(3‐Thienyl)‐3‐Arylacrylonitriles as Antifungal and Anticancer Agents

Author(s) -

Quiroga Jairo,

Cobo Débora,

Insuasty Braulio,

Abonía Rodrigo,

Nogueras Manuel,

Cobo Justo,

Vásquez Yelkaira,

Gupta Mahabir,

Derita Marcos,

Zacchino Susana

Publication year - 2007

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700082

Subject(s) - antifungal , stereochemistry , aryl , chemistry , cancer cell lines , combinatorial chemistry , organic chemistry , cancer , microbiology and biotechnology , biology , cancer cell , alkyl , genetics

A series of 3‐aryl‐2‐(2‐thienyl)acrylonitriles 7 and 3‐aryl‐2‐(3‐thienyl)acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2‐ and 3‐thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively.

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