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Synthesis and Evaluation of Novel E ‐2‐(2‐Thienyl)‐ and Z ‐2‐(3‐Thienyl)‐3‐Arylacrylonitriles as Antifungal and Anticancer Agents
Author(s) -
Quiroga Jairo,
Cobo Débora,
Insuasty Braulio,
Abonía Rodrigo,
Nogueras Manuel,
Cobo Justo,
Vásquez Yelkaira,
Gupta Mahabir,
Derita Marcos,
Zacchino Susana
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700082
Subject(s) - antifungal , stereochemistry , aryl , chemistry , cancer cell lines , combinatorial chemistry , organic chemistry , cancer , microbiology and biotechnology , biology , cancer cell , alkyl , genetics
A series of 3‐aryl‐2‐(2‐thienyl)acrylonitriles 7 and 3‐aryl‐2‐(3‐thienyl)acrylonitriles 8 were synthesized by the reaction of aromatic aldehydes 6 with 2‐ and 3‐thienylacetonitriles 4 and 5, and evaluated for antifungal and cytotoxic activities against a panel of opportunistic and pathogenic fungi and three different cancer cell lines, respectively.