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Synthesis and Antiproliferative In‐Vitro Activity of Natural Flavans and Related Compounds
Author(s) -
Zhang Liang,
Zhang WeiGe,
Ma EnLong,
Wu Lan,
Bao Kai,
Wang XiaoLong,
Wang YuLing,
Song HongRui
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700077
Subject(s) - flavones , chemistry , hela , stereochemistry , flavan , in vitro , flavonoid , hydrogenolysis , biological activity , catalysis , organic chemistry , biochemistry , antioxidant , chromatography
The total synthesis of natural flavan racemates (±) 1 , (±) 2 and natural flavones 3 , 4 had thus been achieved. A straightforward synthetic procedure of flavans via the Pd‐C catalyzed hydrogenation/hydrogenolysis of corresponding flavones was developed. Furthermore, the antiproliferative activities of racemic flavans (±) 1 , (±) 2 , flavones 3 , 4 , and five synthetic intermediates toward human SGC‐7901, BEL‐7402, HeLa, and HL‐60 cell lines in vitro were evaluated by MTT assay, and the racemic flavans (±) 1 were found to have significant antiproliferative activity against all four cell lines.