Synthesis of Four Natural Prenylflavonoids and Their Estrogen‐like Activities | Zendy

Dong Xiaowu | Zendy; Fan Yongjian | Zendy; Yu Lingjun | Zendy; Hu Yongzhou | Zendy

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Synthesis of Four Natural Prenylflavonoids and Their Estrogen‐like Activities

Author(s) -

Dong Xiaowu,

Fan Yongjian,

Yu Lingjun,

Hu Yongzhou

Publication year - 2007

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200700057

Subject(s) - estrogen , chemistry , potency , flavones , flavonoid , biological activity , stereochemistry , biochemistry , in vitro , traditional medicine , endocrinology , antioxidant , biology , medicine , chromatography

Four prenylflavonoids, bavachin 1 , isobavachin 2 , 7,4′‐dihydroxy‐8‐prenylflavone 3 , and 8‐prenylapigenin 4 were synthesized and recognized for possessing estrogen‐like activity in MCF‐7/BOS cells, as evaluated by an estrogen‐screening assay. All compounds significantly stimulated the proliferation of MCF‐7/BOS cells in a dose‐dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1 .

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