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Synthesis of Four Natural Prenylflavonoids and Their Estrogen‐like Activities
Author(s) -
Dong Xiaowu,
Fan Yongjian,
Yu Lingjun,
Hu Yongzhou
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700057
Subject(s) - estrogen , chemistry , potency , flavones , flavonoid , biological activity , stereochemistry , biochemistry , in vitro , traditional medicine , endocrinology , antioxidant , biology , medicine , chromatography
Four prenylflavonoids, bavachin 1 , isobavachin 2 , 7,4′‐dihydroxy‐8‐prenylflavone 3 , and 8‐prenylapigenin 4 were synthesized and recognized for possessing estrogen‐like activity in MCF‐7/BOS cells, as evaluated by an estrogen‐screening assay. All compounds significantly stimulated the proliferation of MCF‐7/BOS cells in a dose‐dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1 .