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Synthesis and Antidiabetic Activity of 3,6,7‐Trisubstituted‐2‐(1 H ‐imidazol‐2‐ylsulfanyl)quinoxalines and Quinoxalin‐2‐yl isothioureas
Author(s) -
Bahekar Rajesh H.,
Jain Mukul R.,
Gupta Arun A.,
Goel Ashish,
Jadav Pradip A.,
Patel Dipam N.,
Prajapati Vijay M.,
Patel Pankaj R.
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700024
Subject(s) - chemistry , quinoxaline , in vitro , stereochemistry , chalcone , medicinal chemistry , biochemistry , organic chemistry
Two series of 3,6,7‐trisubstituted‐2‐( 1H ‐imidazol‐2‐ylsulfanyl)‐quinoxalines 2a‐l and 2‐(quinoxalin‐2‐yl)‐isothioureas 3a‐l were prepared. All the test compounds 2a‐l and 3a‐l were screened in vitro , in a RIN5F cell‐based assay for glucose‐dependent insulinotropic activity. A significant concentration and glucose‐dependent insulin secretion effect was seen with compounds 2a‐l and the insulinotropic activity of compound 2l was found to be identical to that of the standard compound (6,7‐dichloro‐2‐trifluromethyl‐3‐(5‐methyl‐1,3,4‐thiadiazo‐2‐ylsulfanyl)‐quinoxaline ( 1 )).