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Synthesis, Crystal Structure, Cytotoxic and Superoxide Dismutase Activities of Copper(II) Complexes of N ‐(4,5‐Dihydroimidazol‐2‐yl)azoles
Author(s) -
Saczewski Franciszek,
DziemidowiczBorys Ewa,
Bednarski Patrick J.,
Gdaniec Maria
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700021
Subject(s) - chemistry , superoxide dismutase , stereochemistry , cytotoxicity , superoxide , in vitro , chelation , cytotoxic t cell , benzotriazole , enzyme , biochemistry , organic chemistry
Abstract A series of four Cu(II) dichlorides with N ‐(4,5‐dihydro‐1 H ‐imidazol‐2‐yl)azoles as chelating ligands has been prepared and characterized by IR, UV‐vis spectroscopy, and X‐ray crystallography. The complex [ 2 ‐(4,5‐dihydro‐1 H ‐imidazol‐2‐yl)‐1 H ‐benzotriazole]‐dichlorocopper(II) showed very potent SOD activity in vitro with a superoxide scavenging IC 50 of 0.06 μM, comparable to those described in the literature for best low molecular weight SOD mimics. Cytotoxicity studies with seven human tumor cell lines in vitro showed that the most active complexes inhibited the growth of cancer cells with IC 50 between 13–28 μM. No obvious correlation was found between cytotoxic potency and superoxide scavenging activity of the complexes in any of the cell lines.