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Synthesis and Pharmacological Investigation of 3‐Subsituted‐amino‐2‐methylsulfanyl‐5,6,7,8‐tetrahydro‐3 H ‐benzo[4,5]thieno[2,3‐ d ]pyrimidin‐4‐ones as Analgesic and Anti‐Inflammatory Agents
Author(s) -
Alagarsamy V.,
Solomon V. Raja,
Deepa G.,
Parthiban P.,
Anjana G. V.
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200700017
Subject(s) - diclofenac sodium , analgesic , chemistry , pharmacology , diclofenac , stereochemistry , anti inflammatory , biochemistry , medicine , chromatography
In the present work, design, synthesis, and pharmacological evaluation of the analgesic, anti‐inflammatory, and ulcerogenic‐index activities of new 3‐subsituted‐amino‐2‐methylsulfanyl‐5,6,7,8‐tetrahydro‐3 H ‐benzo[4,5]thieno[2,3‐ d ]pyrimidin‐4‐ones, structurally planed by exploiting a clear concept of bio‐isosterism, are reported. All compounds exhibited significant analgesic and anti‐inflammatory activity. Compounds A1, A3 showed higher analgesic activity and more potent anti‐inflammatory activity than that of the reference compound diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to that of acetylsalicylic acid.