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Synthesis, Structure and Hypoxic Cytotoxicity of 3‐Amino‐1,2,4‐benzotriazine‐1,4‐dioxide Derivatives
Author(s) -
Jiang Faqin,
Weng Qinjie,
Sheng Rong,
Xia Qing,
He Qiaojun,
Yang Bo,
Hu Yongzhou
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600201
Subject(s) - cytotoxicity , chemistry , tirapazamine , hypoxia (environmental) , cytotoxic t cell , in vitro , prostate , pharmacology , cancer research , biochemistry , medicine , biology , organic chemistry , oxygen , cancer
A series of novel 3‐amino‐1,2,4‐benzotriazine‐1,4‐dioxide derivatives were synthesized and screened for their in vitro cytotoxicity against promyelocytic leukemia HL‐60, androgen‐independent prostate tumor PC3, hepatocellular carcinoma Bel‐7402, human esophagus tumor ECA‐109, and human breast tumor MCF‐7 cell lines in hypoxia and in normoxia. Most compounds showed higher cytotoxic activity both in hypoxia and in normoxia. Among them, compounds 61 and 62 showed more potent cytotoxic activity and hypoxic selectivity when compared to tirapazamine.