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Synthesis of Novel 1‐Pyrazolylpyridin‐2‐ones as Potential Anti‐Inflammatory and Analgesic Agents
Author(s) -
Ismail Magda M. F.,
Ammar Yousry A.,
ElZahaby Heba S. A.,
Eisa Sally I.,
ElSayed Barakat Saber
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600197
Subject(s) - analgesic , chemistry , pyridine , pyrimidine , biological activity , stereochemistry , aryl , chemical synthesis , pharmacology , dihydropyridine , analgesic agents , alkyl , combinatorial chemistry , medicinal chemistry , in vitro , organic chemistry , biochemistry , medicine , calcium
A new series of 4‐alkyl/aryl‐2‐oxo‐1‐pyrazolyl‐1,2‐dihydropyridine‐3‐carbonitriles, pyrazolo[3,4‐ b ]pyridine‐5‐carbonitriles and pyrido[2,3‐ d ]pyrimidine‐6‐carbonitriles have been synthesized and tested for their anti‐inflammatory and analgesic activities. Among the tested compounds, 3e and 8b exhibited comparable anti‐inflammatory activity to the standard (indomethacin). Compounds 5 , 7a , and 8b displayed potent analgesic activity. Detailed syntheses, spectroscopic and biological data are reported.