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Synthesis of New ( N α ‐Dipicolinoyl)‐bis‐ L ‐valyl‐ L ‐phenylalanyl Linear and Macrocyclic Bridged Peptides as Anti‐Inflammatory Agents
Author(s) -
Amr Abd ElGalil E.,
AboGhalia Mohamed H.,
Abdalah Mohamed M.
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600187
Subject(s) - chemistry , cyclic peptide , anti inflammatory , peptide , stereochemistry , diclofenac , combinatorial chemistry , pharmacology , biochemistry , medicine
In continuation to our search for new chiral macrocyclic peptide‐based anti‐inflammatories, the suggestion, synthesis, structure elucidation of some N α ‐ bis ‐dipicolinoyl amino acids, linear, tetra and cyclic (penta and octa)‐bridged peptides 3–10 , were realized herein. The newly synthesized compounds showed potent anti‐inflammatory activity with low toxicity (LD 50 ) comparable to indomethacin and diclofenac as reference anti‐inflammatory drugs.