Synthesis of New ( N   α ‐Dipicolinoyl)‐bis‐ L ‐valyl‐ L ‐phenylalanyl Linear and Macrocyclic Bridged Peptides as Anti‐Inflammatory Agents | Zendy

Amr Abd ElGalil E. | Zendy; AboGhalia Mohamed H. | Zendy; Abdalah Mohamed M. | Zendy

Premium

Synthesis of New ( N α ‐Dipicolinoyl)‐bis‐ L ‐valyl‐ L ‐phenylalanyl Linear and Macrocyclic Bridged Peptides as Anti‐Inflammatory Agents

Author(s) -

Amr Abd ElGalil E.,

AboGhalia Mohamed H.,

Abdalah Mohamed M.

Publication year - 2007

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.200600187

Subject(s) - chemistry , cyclic peptide , anti inflammatory , peptide , stereochemistry , diclofenac , combinatorial chemistry , pharmacology , biochemistry , medicine

In continuation to our search for new chiral macrocyclic peptide‐based anti‐inflammatories, the suggestion, synthesis, structure elucidation of some N α ‐ bis ‐dipicolinoyl amino acids, linear, tetra and cyclic (penta and octa)‐bridged peptides 3–10 , were realized herein. The newly synthesized compounds showed potent anti‐inflammatory activity with low toxicity (LD 50 ) comparable to indomethacin and diclofenac as reference anti‐inflammatory drugs.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research