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Synthesis and Antioxidant Properties of Novel N ‐H and N ‐Substituted Propanamide Derivatives
Author(s) -
Ölgen Süreyya,
Kılıç Zuhal,
Ada Ahmet O.,
Çoban Tülay
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600176
Subject(s) - lipid peroxidation , indole test , chemistry , oxidative stress , antioxidant , superoxide , oxidative phosphorylation , chemical synthesis , stereochemistry , biochemistry , in vitro , enzyme
The interest in the application of antioxidants for medical treatment has been growing recently. A lot of evidence has proven the link between the development of human diseases and oxidative stress. Indole derivatives were found to be very effective in protecting against oxidative stress. Recent exciting findings have demonstrated that several indole derivatives (IDs) are strong inhibitors of superoxide anion (SOD) and lipid peroxidation (LP). In this study, a series of novel N ‐H and N ‐substituted indole‐3‐propanamide derivatives (I3PADs) have been prepared and their efficiencies were investigated towards SOD and LP. Among the synthesized I3PADs, compounds 5 and 7‐12 significantly inhibited O 2 ∗ – in the range of 94–100%. In addition, N ‐H I3PADs showed a stronger inhibitory effect (compounds 1–5 , 56–83%) on lipid peroxidation levels than SOD.