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Synthesis and Anti‐proliferative in‐vitro Activity of Two Natural Dihydrostilbenes and their Analogues
Author(s) -
Zhang WeiGe,
Zhao Rui,
Ren Jian,
Ren LiXiang,
Lin JinGuang,
Liu DaiLin,
Wu YingLiang,
Yao XinSheng
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600146
Subject(s) - cytotoxicity , chemistry , in vitro , cancer cell lines , cell culture , stereochemistry , mtt assay , wittig reaction , biochemistry , cancer cell , biology , cancer , genetics
A total synthetic route for two natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines, (3‐(2‐(7‐methoxybenzo[ d ][1,3]dioxol‐5‐yl)ethyl)phenol 1a and 6‐(3‐hydroxyphenethyl)benzo[ d ][1,3]dioxol‐4‐ol 1b ), which were isolated from Bulbophyllum odoratissimum Lindl, was developed via Wittig–Horner reaction. The natural products 1a and 1b were obtained in 28% and 20% overall yield, respectively. Additionally, nine analogues, 1c ‐ 1k , of the two natural dihydrostilbenes were synthesized and evaluated for their anti‐proliferative activity against human SGC‐7901, KB and HT‐1080 cell lines by MTT assay. The activities of 1c and 1d were in the same range as those of the natural products 1a and 1b .