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A Large Scale Synthesis of a Natural Antibiotic, 2,4‐Diacetylophloroglucinol (DAPG)
Author(s) -
Zakrzewski Jerzy,
Karpińska Monika,
Maliński Zbigniew
Publication year - 2007
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.200600139
Subject(s) - acetic anhydride , chemistry , phloroglucinol , column chromatography , boron trifluoride , acetic acid , boiling , chromatography , organic chemistry , catalysis
A natural antibiotic, 2,4‐diacetylophloroglucinol (DAPG), has been prepared by the acetylation of phloroglucinol (PhL) with acetic anhydride in the presence of boron trifluoride etherate complex. The crude DAPG is efficiently purified using chromatographic filtration with boiling eluent.